Background: A prospective, randomized, placebo-controlled clinical trial was conducted to compare the healing
effectiveness of Alkanna tinctoria (L.) Tausch (Boraginaceae) with standard dressing on wound healing at the donor
site after removal of the skin graft.
Methods: Enrolled patients were randomly allocated to receive topicalA. tinctoria extract ointment (20%) or
standard dressing (dressing with base ointment) daily. Wound healing was assessed using the Bates-Jenson
assessment tool at the 2nd and 4th weeks after intervention.
Results: Decreases in wound score were significantly greater in the A. tinctoria group compared with the placebo
group (P <0.05). The surface areas of graft donor sites in the A. tinctoria group were significantly reduced as compared
with the control group at day 28 of the intervention (P < 0.05). The proportion of patients in the A. tinctoria group
achieving complete wound healing within 2 to 4 weeks was 50% and 96.66%, respectively, significantly higher than in
patients receiving standard care: 0% and 23.3%, respectively.
Conclusions: This clinical study showed that A. tinctoria dressing accelerates wound healing after graft harvesting.
Trial registration: IRCT ID: IRCT201511165781N2.
Keywords: Alkanna, Skin graft, Wound, Healing