Tehran University of Medical Sciences
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Ghasemali Khorasani

درمان اسكار هيپرتروفيك با تزريق داخل ضايع هاي توكسين بوتولينوم نوع :A كارآزمايي باليني تصادفي داراي گروه شاهد و دوسوكور

Authors: دكتر احمدرضا طاهري, دكتر قاسمعلي خراساني, دكتر سيامك فرقاني, دكتر افشين فتحي1
Keywords: توكسين بوتولينوم نوع A ,اسكار هيپرتروفيك، تزريق داخل ضايعه
پوست و زيبايي, Vol.7, No.1, 1395,Page:10-16

Treatment of hypertrophic scar with intralesional injection of
botulinum toxin A: A double-blind, randomized controlled
clinical trial

Background and Aim: Hypertrophic scars are highly
resistant to the treatment and have a high recurrence rate.
Affected patients suffer from aesthetic and functional
complications, which may influence their quality of life.
Nowadays, various therapeutic modalities have been used in
the treatment of hypertrophic scars, but patients' problems
remain because of high recurrence rate. This study evaluated
the efficacy of intralesional injection of botulinum toxin A in
the treatment of hypertrophic scar lesions.
Methods: This randomised controlled trial was performed
during 2014 and 2015. Each patient`s lesion was randomly
allocated in ine of the two arms of the study: one half of the
lesion received monthly 8 IU/cm3 of 200 IU/ml intralesional
botulinum toxin A (Dysport, Ipsen Biopharma Ltd., UK) and
the other half was injected with the same volume of normal
saline. Injections were repeated three times. After 9 months,
lesions were evaluated according to Vancouver scar scale.
Results: Twenty-one patients with a mean age of 27.2 years
completed the study. In the intervention the mean lesions`
pigmentation scale decrease to 0.73, vascularity to 0.9 and
pliability to 0.98 (P<0.01), but there was no significant
change in lesions height (P=0.32).
Conclusion: It seems that injection of botulinum toxin A in
hypertrophic scar lesions acts as useful adjuvant for other
treatment methods.
Keywords: botulinum toxin A, hypertrophic scar,
intralesional injection