Tehran University of Medical Sciences
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Azadeh Ebrahim-Habibi

Contact Information
Address: Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Scie
Academic Rank
Research Center
Endocrinology and Metabolism Research Center
CV last edited on: 2020/10/06


Postdoctoral fellowship

Institut für Pharmazeutische und Medizinische Chemie, Pharmacy , Düsseldorf, Germany, 2006-2007

Project title: Homology modeling of a glucosidase enzyme

Under supervision of Professor Hans-Dieter Hoeltje



Biochemistry, University of Tehran , Tehran, Iran, Thesis Title:Chemical modification of alpha-amylase
Supervisor:Professor Mohsen Nemat-Gorgani

Pharm D

Pharmacy, School of Pharmacy of the Azad University, Tehran, Iran, 1997


Speaking: Native, Reading: Native, Writing: Native

French -close to native

Speaking: Native, Reading: Native, Writing: Native

English-written, read, spoken


German -Zertifikat Deutsch, grade: 1


Selected as best 2004 Biochemistry Ph.D. candidate of IBB


Ranked second between fellow students of the Pharm.D. program


Scientific Position


Assistant Professor

Tehran University of Medical Sciences,

Associate Professor

Tehran University of Medical Sciences, 2012


Tehran University of Medical Sciences, 2017



Protein Chemistry

دانشکده داروسازی دانشگاه تهران ,Ph.D.



Protein Structure

Ph.D, Science and Research Branch Aza,-.


M.Sc. and Ph.D, Science and Research Branch Aza,-.

Enzymes Mechanism of Action

Ph.D, Science and Research Branch Aza,-.

Introduction to Medicinal Chemistry

M.Sc, Science and Research Branch Aza,-.

Special Topics in Biochemistry

M.Sc, Science and Research Branch Aza,-.

Molecular Modeling : Basics

EMRI, Coordinator, Organizer



Molecular modeling and in vitro study on proposed lipase inhibitors

Biochemistry, M.Sc. Thesis, 2011

Study on the effects of some phenol and purine compounds on alpha-amylase activity using a direct kinetic assay

Biochemistry, M.Sc. Thesis, 2011

Comparative study of organic solvents effect on insulin aggregation

Biochemistry, M.Sc. Thesis., 2010

Biotechnology, M.Sc. Thesis

Biochemistry, M.Sc. Thesis , 2010

Study on the effect of natural compounds on amyloid formation of insulin.

Biotechnology, M.Sc. Thesis, 2010

Chemical modification of the lysine residue of bovine insulin and studying modified protein structure and aggregation in vitro

Biochemistry, M.Sc. Thesis, 2009

Molecular modeling studies on bacterial acetate kinase: studying the active site and design of inhibitors

Biochemistry, M.Sc. Thesis, 2009

Study on the inhibitory effect of polyphenolic compounds on alpha-amylase enzymes from Aspergillus oryzae, Sus scrofa and human

Biochemistry, M.Sc. Thesis, 2008

Investigation of the effect of several natural compounds on the activity of alpha amylase and level of blood sugar in diabetic

Ph.D, Biochemistry, Ph.D. Thesis, 2010



Advisor for 18 M.Sc. theses (Biochemistry,Biophysics) between


A comparative study on amyloid fibril formation in apo and holo bovine carbonic anhydrase II

Ph.D, Biochemistry, Ph.D. Thesis, 2012

Induction and characterization of intermediate structures in glutamate dehydrogenase leading to its aggregation.

Ph.D, Biochemistry, Ph.D. Thesis, 2008

duction of amyloid aggregation of bovine alpha-chymotrypsin and biochemical and biophysical characterization of its intermediate

Ph.D, Biochemistry, Ph.D. Thesis, 2007



-Book Chapter-Pheochromocytoma –A New View of the Old Problem Edited By: Jose Fernando Martin

Authors: Shirin Hasani-Ranjbar, Azadeh Ebrahim-Habibi and Bagher Larijani
Publisher: InTech, 2011, Original




Drug repurposing using computational methods to identify therapeutic options for COVID-19

Authors: Soodeh Mahdian, Azadeh Ebrahim-Habibi, Mahboobeh Zarrabi
Journal of Diabetes and Metabolic Disorders, Year. 2020,

Investigating the role of endogenous opioid system in chloroquine‐induced phospholipidosis in rat liver by morphological, biochemical and molecular modelling studies

Authors: Mohammad Reza Malek, Shahin Ahmadian, Ahmad Reza Dehpour, Azadeh Ebrahim‐Habibi, Mahshid Shafizadeh, Elaheh Kashani‐Amin
Clinical and Experimental Pharmacology and Physiology, Year. 2020,

Betanin effect on PPAR-α and SREBP-1c expression in NMRI mice model of steatohepatitis with fibrosis

Authors: L Yahaghi, Parichehreh Yaghmaei, N Hayati-Roodbari, S Irani, A Ebrahim-Habibi
Physiology International, Year. 2020,

Glycyrrhizin improves fatty liver symptoms, increases adiponectin and reduces UCP2 expression in Wistar rats

Authors: Hamedeh Bagheri, Parichehreh Yaghmaei, Mohamadhosein Modaresi, Marjan Sabbaghian, Azadeh Ebrahim-Habibi
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, Vol.90, No.1, Year. 2020, Page:191-197,

Characterization of arginine preventive effect on heat-induced aggregation of insulin

Authors: Sepideh Haghighi-Poodeh, Boris Kurganov, Latifeh Navidpour, Parichehreh Yaghmaei, Azadeh Ebrahim-Habibi
International journal of biological macromolecules, Vol.145, Year. 2020, Page:1039-1048,

Presence of carbohydrate binding modules in extracellular region of class C G-protein coupled receptors (C GPCR): An in silico investigation on sweet taste receptor

Authors: Elaheh Kashani-Amin, Amirhossein Sakhteman, Bagher Larijani, Azadeh Ebrahim-Habibi
Journal of Biosciences, Vol.44, No.6, Year. 2019, Page:138,

Monocyclic phenolic compounds stabilize human insulin and suppress its amorphous aggregation: In vitro and in vivo study

Authors: Sepideh Haghighi-Poodeh, Latifeh Navidpour, Parichehreh Yaghmaei, Azadeh Ebrahim-Habibi
Biochemical and biophysical research communications, Vol.518, No.2, Year. 2019, Page:362-367,

Amino acids as additives against amorphous aggregation: in vitro and in silico study on human lysozyme

Authors: Naghmeh Saadati-Eskandari, Latifeh Navidpour, Parichehreh Yaghmaei, Azadeh Ebrahim-Habibi
Applied biochemistry and biotechnology, Vol.189, No.1, Year. 2019, Page:305-317,

Introducing a New Model of Sweet Taste Receptor, a Class C G-protein Coupled Receptor (C GPCR)

Authors: Elaheh Kashani-Amin, Amirhossein Sakhteman, Bagher Larijani, Azadeh Ebrahim-Habibi
Cell biochemistry and biophysics, Vol.77, No.3, Year. 2019, Page:227-243,

Virtual Screening of Henna Compounds Library for Discovery of New Leads against Human Thymidine Phosphorylase, an Overexpressed Factor of Hand-Foot Syndrome

Authors: Davood Khodabakhshi-Javinani, Azadeh Ebrahim-Habibi, Minoo Afshar, Latifeh Navidpour
Letters in Drug Design & Discovery, Vol.16, No.6, Year. 2019, Page:625-636,

Inhibition of amyloid fibrillation of apo-carbonic anhydrase by flavonoid compounds

Authors: Ali Es-haghi, Azadeh Ebrahim-Habibi
Journal of biosciences, Vol.44, No.2, Year. 2019, Page:46,

A systematic review on popularity, application and characteristics of protein secondary structure prediction tools

Authors: Elaheh Kashani-Amin, Ozra Tabatabaei-Malazy, Amirhossein Sakhteman, Bagher Larijani, Azadeh Ebrahim-Habibi
Current drug discovery technologies, Vol.16, No.2, Year. 2019, Page:159-172,

Effects of Eugenol on Alzheimer’s Disease-like Manifestations in Insulin-and Aβ-Induced Rat Models

Authors: P Taheri, P Yaghmaei, H Sepasi Tehrani, A Ebrahim-Habibi
Neurophysiology, Vol.51, No.2, Year. 2019, Page:114-119,

Aurones as New Porcine Pancreatic α-Amylase Inhibitors

Authors: Khashayar Roshanzamir, Elaheh Kashani-Amin, Azadeh Ebrahim-Habibi, Latifeh Navidpour
Letters in Drug Design & Discovery, Vol.16, No.3, Year. 2019, Page:333-340,

Influence of dendrimer surface chemistry and pH on the binding and release pattern of chalcone studied by molecular dynamics simulations

Authors: Farideh Badalkhani‐Khamseh, Azadeh Ebrahim‐Habibi, Nasser L Hadipour
Journal of Molecular Recognition, Vol.32, No.1, Year. 2019, Page:e2757,

Effects of thymol on amyloid-β-induced impairments in hippocampal synaptic plasticity in rats fed a high-fat diet

Authors: Masoumeh Asadbegi, Alireza Komaki, Iraj Salehi, Parichehreh Yaghmaei, Azadeh Ebrahim-Habibi, Siamak Shahidi, Abdolrahman Sarihi, Sara Soleimani Asl, Zoleikha Golipoor
Brain research bulletin, Vol.137, Year. 2018, Page:338-350,

Acetylation of lysine residues in apomyoglobin: Structural changes, amyloid fibrillation, and role of surface charge

Authors: Mehrnaz Azami-Movahed, Ali Akbar Meratan, Atiyeh Ghasemi, Azadeh Ebrahim-Habibi, Mohsen Nemat-Gorgani
International journal of biological macromolecules, Vol.107, Year. 2018, Page:626-634,

Citral effect in male NMRI mice nonalcoholic steatosis model: assessing biochemical and histological parameters and PPARα gene expression

Authors: Maryam Vaezi, Parichehreh Yaghmaei, Nasim Hayati-Roodbari, Shiva Irani, Azadeh Ebrahim-Habibi
Brazilian Journal of Pharmaceutical Sciences, Vol.54, No.3, Year. 2018,

Role of Cymene in the attenuation of fatty liver and UCP2 gene expression

Authors: Hamedeh Bagheri, Parichehreh Yaghmaei, Mohamadhosein Modaresi, Azadeh Ebrahim-Habibi, Marjan Sabbaghian
Medical Science, Vol.22, No.90, Year. 2018, Page:232-242,

Astaxanthin effectiveness in preventing multiple sclerosis in animal model

Authors: S Bidaran, AR Ahmadi, P Yaghmaei, MH Sanati, A Ebrahim-Habibi
Bratislavske lekarske listy, Vol.119, No.3, Year. 2018, Page:160-166,

Silver nano particles ameliorate learning and spatial memory of male Wistar rats by prevention of amyloid fibril-induced neurotoxicity

Authors: H Ramshini, AS Moghaddasi, LS Aldaghi, N Mollania, A Ebrahim-Habibi
Archives italiennes de biologie, Vol.155, Year. 2017, Page:131-141,

Atomistic computer simulations on multi-loaded PAMAM dendrimers: A comparison of amine-and hydroxyl-terminated dendrimers

Authors: Farideh Badalkhani-Khamseh, Azadeh Ebrahim-Habibi, Nasser L Hadipour
Journal of computer-aided molecular design, Vol.31, No.12, Year. 2017, Page:1097-1111,

Effect of Organic Solvents on Porcine Pancreatic Lipase Thermal Aggregation

Authors: Mahsa Vaezzadeh, Marjan Sabbaghian, Parichehreh Yaghmaei, Azadeh Ebrahim-Habibi
Protein and peptide letters, Vol.24, No.10, Year. 2017, Page:955-961,

Complexation of nicotinic acid with first generation poly (amidoamine) dendrimers: A microscopic view from density functional theory

Authors: Farideh Badalkhani-Khamseh, Aidin Bahrami, Azadeh Ebrahim-Habibi, Nasser L Hadipour
Chemical Physics Letters, Vol.684, Year. 2017, Page:103-112,

Therapeutic protein deimmunization by T‐cell epitope removal: antigen‐specific immune responses in vitro and in vivo

Authors: Saeme Asgari, Azadeh Ebrahim‐Habibi, Mehdi Mahdavi, Mohammad Choopani, Hasan Mirzahoseini
Apmis, Vol.125, No.6, Year. 2017, Page:544-552,

Investigation of thymol effect on learning and memory impairment induced by intrahippocampal injection of amyloid beta peptide in high fat diet-fed rats

Authors: Masoumeh Asadbegi, Parichehreh Yaghmaei, Iraj Salehi, Alireza Komaki, Azadeh Ebrahim-Habibi
Metabolic Brain Disease, Vol.32, No.3, Year. 2017, Page:827-839,

Turmeric effect on subcutaneous insulin-induced amyloid mass: an in vivo study

Authors: Raheleh Kheirbakhsh, Maryam Chinisaz, Saeid Amanpour, Shahab Amini, Saeed Khodayari, Hamid Khodayari, Aydin Dilmaghanian, Mahnaz Haddadi, Azadeh Ebrahim-Habibi
Drug and chemical toxicology, Vol.40, Year. 2017, Page:1-6,

Characterization of surface binding sites in glycoside hydrolases: A computational study

Authors: Samaneh Samaei‐Daryan, Bahram Goliaei, Azadeh Ebrahim‐Habibi
Journal of Molecular Recognition, Year. 2017,

Structure and function of anhydride-modified forms of human insulin: In silico, in vitro and in vivo studies

Authors: Maryam Chinisaz, Azadeh Ebrahim-Habibi, Ahmad-Reza Dehpour, Parichehreh Yaghmaei, Kazem Parivar, Ali Akbar Moosavi-Movahedi
European Journal of Pharmaceutical Sciences, Vol.96, Year. 2017, Page:342-350,

Amyloid-like aggregates formation by bovine apo-carbonic anhydrase in various alcohols: A comparative study

Authors: Ali Es-haghi, Azadeh Ebrahim-Habibi, Marjan Sabbaghian, Mohsen Nemat-Gorgani
International journal of biological macromolecules, Vol.92, Page:573-580,

Bis (indolyl) phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme

Authors: Hassan Ramshini, Benedetta Mannini, Kaveh Khodayari, Azadeh Ebrahim-Habibi, Azam Sadat Moghaddasi, Reza Tayebee, Fabrizio Chiti
European journal of medicinal chemistry, Vol.124, Year. 2016, Page:361-371,

Effect of trans-chalcone on atheroma plaque formation, liver fibrosis and adiponectin gene expression in cholesterol-fed NMRI mice

Authors: Leyla Karkhaneh, Parichehreh Yaghmaei, Kazem Parivar, Majid Sadeghizadeh, Azadeh Ebrahim-Habibi
Pharmacological Reports, Vol.68, No.4, Year. 2016, Page:720-727,

Benzothiazole Thioflavin T improves obesity-related symptoms in mice

Authors: Fatemeh Jalalvand, Mahsa M Amoli, Parichehreh Yaghmaei, Masoud Kimiagar, Azadeh Ebrahim-Habibi
Periodicum Biologorum, Vol.118, No.2, Year. 2016,

Acarbose and the thermal aggregation of Bacillus amyloliquefaciens alpha‐amylase (BAA): protective effect of an inhibitor

Authors: Hanieh Shojaee, Marjan Sabbaghian, Azadeh Ebrahim‐Habibi
Journal of Chemical Technology and Biotechnology, Vol.91, No.5, Year. 2016, Page:1397-1402,

Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet

Authors: Masoumeh Asadbegi, Parichehreh Yaghmaei, Iraj Salehi, Azadeh Ebrahim-Habibi, Alireza Komaki
Brain research bulletin, Year. 2016,

Rational design of stable and functional hirudin III mutants with lower antigenicity

Authors: Saeme Asgari, Hasan Mirzahoseini, Morteza Karimipour, Hamze Rahimi, Azadeh Ebrahim-Habibi

Bacterial expression and characterization of an active recombinant lipase A from Serratia marcescens with truncated C-terminal region

Authors: Mohammadi M, Sepehrizadeh Z, Ebrahim-Habibi A, Shahverdi AR, Faramarzi MA, Setayesh N
Journal of Molecular Catalysis B: Enzymatic,

Acarbose versus trans-chalcone : comparing the effect of two glycosidase inhibitors on obese mice

Authors: Jalalvand F, Amoli MM, Yaghmei P, Kimiagar M, Ebrahim-Habibi A
Arquivos Brasileiros de Endocrinologia & Metabologia,

Inhibition of amyloid fibril formation and cytotoxicity by a chemical analog of curcumin as a stable inhibitor

Authors: Ramshini H., Mmohammad-Zadeh M., Ebrahim-Habibi A
International Journal of Biological Macromolecules,

UV spectrophotometric determination and validation of hydroquinone in liposome

Authors: Khoshneviszadeh R., Bazzaz BSF., Housaindokht MR, Ebrahim-Habibi A., Rajabi O.
Iranian Journal of Pharmaceutical Research, Vol.14, No.2, Year. 2015, Page:473-478,

Injection of insulin amyloid fibrils in the hippocampus of male Wistar rats : report on memory impairment and formation of amyloid plaques

Authors: Kheirbakhsh R, Chinisaz M, Khodayari S, Amanpour S, Dehpour AR, Muhammadnejad A, Larijani B, Ebrahim-Habibi* A
Neurological Sciences ,

. Segregation of a novel homozygous 6 nucleotide deletion in GLUT2 gene in a Fanconi-Bickel syndrome family.

Authors: Abbasi F, Azizi F, Javaheri M, Mosallanejad A, Ebrahim-Habibi A, Ghafouri-Fard S
Gene, Vol.557, No.1, Year. 2015, Page:103-105,

Effect of neohesperidin dihydrochalcone on the activity and stability of alpha-amylase: a comparative study on bacterial, fungal, and mammalian enzymes

Authors: Kashani-Amin E, Ebrahim-Habibi A*, Larijani B, Moosavi-Movahedi AA
Journal of Molecular Recognition,

Structural stability of myoglobin and glycomyoglobin: A comparative molecular dynamics simulation study

Authors: Alizadeh-Rahrovi J, Shayesteh A*, Ebrahim-Habibi *A
Journal of Biological Physics,

Thioflavin T effect in diabetic Wistar rats: Reporting the antihyperglycemic property of an amyloid probing dye

Authors: Najafian, M., Amini, S., Dehestani, B., Parivar, K., Ebrahim-Habibi, A
Pharmacological Reports, Vol.67, Year. 2015, Page:364-369,

Interaction of Aβ(25-35) Fibrillation Products with Mitochondria: Effect of Small-Molecule Natural Products

Authors: Ghobeh M, Ahmadian S, Meratan AA, Ebrahim-Habibi A, Ghasemi A, Shafizadeh M, Nemat-Gorgani M
Biopolymers: Peptide Science , Vol.102, No.6, Year. 2014, Page:473-476,

A novel missense mutation in oncostatin m receptor Beta causing primary localized cutaneous amyloidosis

Authors: Saeedi M, Ebrahim-Habibi A, Haghighi A, Zarrabi F, Amoli MM, Robati RM
Biomed Res Int, Year. 2014,

Applications of molecular modeling in endocrinology

Authors: Ebrahim-Habibi A., Larijani B
Iranian Journal of Public Health, Vol.43, Year. 2014,

A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS)

Authors: Abbasi, F., Ghafouri-Fard, S., Javaheri, M., Dideban, A., Ebrahimi, A., Ebrahim-Habibi, A
Gene, Vol.542, No.2, Year. 2014, Page:269-271,

A molecular modeling study on full length insulin: insight into initial events of amyloid formation

Authors: Chinisaz M, Larijani B, Ebrahim-Habibi *A
Structural Chemistry, Year. In Press,

Generating local amyloidosis in mice by subcutaneous injection of human insulin amyloid

Authors: Chinisaz M, Ebrahim-Habibi A, Yaghmaei P, Parivar K, Dehpour A-R
Experimental and Therapeutic Medicine Journal, Year. Accepted,

Ectopic Cushing syndrome associated with thymic carcinoid tumor as the first presentation of MEN1 syndrome-report of a family with MEN1 gene mutation

Authors: Hasani-Ranjbar S, Rahmanian M, Ebrahim-Habibi A, Soltani A, Soltanzade A, Mahrampour E, Amoli MM
Familial Cancer, Year. Accepted,

Production of insulin amyloid nanofibrils in organic solvents: a comparative study

Authors: Nemati-Lay M., Nemati-Lay E., Larijani B., Ebrahim-Habibi *A
Minerva Biotecnologica, Year. Accepted,

Silymarin effect on amyloid ß plaque accumulation and gene expression of APP in an Alzheimer’s disease rat model

Authors: Yaghmaei P.*, Azarfar K., Dezfulian M. , Ebrahim-Habibi *A
DARU, Vol.22:24, Year. 2014,

Amyloid formation and inhibition of an all-beta protein: a study on fungal polygalacturonase

Authors: Chinisaz M, Ghasemi A, Larijani B, Ebrahim-Habibi* A
Journal of Molecular Structure , Vol.1059, Year. 2014, Page:94–100,

Indole and trans–chalcone attenuate amyloid beta plaque accumulation in male Wistar rat: in vivo effectiveness of two anti-amyloid scaffolds

Authors: Yaghmaei P, Kheirbakhsh R, Dezfulian M, Haeri-Rohani A, Larijani B, Ebrahim-Habibi *A
Archives Italiennes de Biologie , Vol.151, No.3, Year. 2013, Page:106-113,

Targeting acetate kinase: inhibitors as potential bacteriostatics

Authors: Asgari S., Shariati * P., Ebrahim-Habibi* A.
Journal of Microbiology and Biotechnology, Vol.23, Year. 2013, Page:1544-1553 ,

How curcumin affords effective protection against amyloid fibrillation in insulin

Authors: Rabiee A., Ebrahim-Habibi *A, Ghasemi A., Nemat-Gorgani*M..
Food and Function , Vol.4, Year. 2013, Page:1474-1480,

Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha- amylase as an allosteric effector

Authors: Kashani-Amin E, Larijani B,Ebrahim-Habibi *A
FEBS Letters, Vol.587, No.6, Year. 2013, Page:652-8,

Reflection on design and testing of pancreatic alpha-amylase inhibitors: an in silico comparison between rat and rabbit enzyme models

Authors: Khalil-Moghaddam S, Ebrahim-Habibi A, Pasalar P, Yaghmaei P, Hayati-Roodbari N
DARU Journal of Pharmaceutical Sciences , Vol.20, No.77, Year. 2012,

Heme binding site in apomyoglobin may be effectively targeted with small molecules to control aggregation

Authors: Azami-Movahed M, Shariatizi S, Sabbaghian M, Ghasemi A, Ebrahim-Habibi* A, Nemat-Gorgani* M
The international journal of biochemistry & cell biology, Vol.45, Year. 2013, Page: 299– 307 ,

Maternal zinc intake of Wistar rats has a protective effect in the alloxan-induced diabetic offspring

Authors: Yaghmaei* P, Esfahani-Nejad H, Ahmadi R, Hayati-Roodbari N, Ebrahim-Habibi *A
Journal of Physiology and Biochemistry, Year. 2012,

Xanthine derivatives as activators of alpha-amylase: Hypothesis on a link with the hyperglycemia induced by caffeine

Authors: Kashani-Amin E, Yaghmaei P, Larijani B, Ebrahim-Habibi* A
Obesity Research & Clinical Practice, Year. 2012,

Response surface methodology for optimizing the bovine serum albumin fibrillation

Authors: Arasteh A, Habibi-Rezaei M, Ebrahim-Habibi A, Moosavi-Movahedi AA
The Protein Journal, Vol.31, No.6, Year. 2012, Page:457-465,

Thermal disaggregation of type B yeast hexokinase by indole derivatives: a mechanistic study

Authors: Ramshini H, Ebrahim-Habibi A
International Journal of Biological Macromolecules, Vol.50, No.5, Year. 2012, Page:1260-1266,

Amyloid fibrillation in native and chemically-modified forms of carbonic anhydrase II: Role of surface hydrophobicity.

Authors: Es-haghi A., Shariatizi S., Ebrahim-Habibi A., Nemat-Gorgani M
Biochimica et Biophysica Acta, Vol.1824, No.3, Year. 2012 , Page:468-477,

Detection of KCNJ11 Gene Mutations in a Family with Neonatal Diabetes: Implications for Therapeutic Management of Family Members with Long-Standing Disease

Authors: Abbasi F, Saba S, Ebrahim-Habibi* A, Sayahpour FA, Amiri P, Larijani B, Amoli* MM
Molecular Diagnosis & Therapy, Vol.16, No.2, Year. 2012, Page:109-114,

Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase

Authors: Najafian M, Ebrahim-Habibi A*, Hezareh N, Yaghmaei P, Parivar K, Larijani B)
Molecular Biology Reports, Vol.38, Year. 2011, Page:1617-1620,

Novel mutations of wolframin: a report with a look at the protein structure

Authors: A, Ebrahim-Habibi A*, Abbasi F*, Amoli M, Sayahpour FA, Larijani B
Clinical Genetics, Vol.79, Year. 2011, Page:96-99,

new frameshift MEN1 gene mutation associated with familial malignant insulinomas.

Authors: Hasani-Ranjbar S, Amoli MM, Ebrahim-Habibi A, Gozashti MH, Khalili N, Sayyahpour FA, Hafeziyeh J, Soltani A, Larijani B
Familial Cancer, Vol.10, Year. 2011, Page:343-348,

-Effects of Sucrose and Trehalose on Stability, Kinetic Properties, and Thermal Aggregation of Firefly Luciferase

Authors: Rasouli S, Hosseinkhani S, Yaghmaei P, Ebrahim-Habibi A.
Applied Biochemistry and Biotechnology., Vol.165, No.2, Year. 2011, Page:572-82,

Prevention of thermal aggregation of an allosteric protein by small molecules: Some mechanistic insights

Authors: Sabbaghian M, Ebrahim-Habibi A, Hosseinkhani S, Ghasemi A, Nemat-Gorgani M
International Journal of Biological Macromolecules, Vol.49, No.4, Year. 2011, Page:806-13,

Benzofuranone derivatives as effective small molecules related to insulin amyloid fibrillation: a structure-function study

Authors: Rabiee A, Ebrahim-Habibi A*, Navidpour L, Morshedi D, Ghasemi A, Sabbaghian M, Nemati-Lay M, Nemat-Gorgani* M
Chemical Biology and Drug Design, Vol.78, No.4, Year. 2011, Page:659-66 ,

-Immobilization of acetylcholinesterase in nanofibrous PVA/BSA membranes by electrospinning

Authors: Moradzadegan A., Ranaei-Siadat S-O., Ebrahim-Habibi A., Barshan-Tashnizi M., Jalili R., Torabi S-F, Khajeh K
Engineering in Life Sciences, Vol.10, Year. 2010, Page:57-64,

Fibrillation of alpha-lactalbumin: effect of crocin and safranal, two natural small molecules from Crocus sativus.

Authors: Ebrahim-Habibi M-B., Amininasab M., Ebrahim-Habibi A., Sabbaghian M., Nemat-Gorgani M.
Biopolymers, Vol.93, Year. 2010, Page:854-865,

Protein-protein interactions leading to aggregation: perspectives on mechanism,significance and control

Authors: Ebrahim-Habibi A., Morshedi D., Rezaei-Ghaleh N., Sabbaghian M., Nemat-Gorgani M
Journal of the Iranian Chemical Society, Vol.7, Year. 2010, Page:521-544,

Chemical modification of lysine residues in lysozyme may dramatically influence its amyloid fibrillation

Authors: Morshedi D., Ebrahim-Habibi A., Moosavi-Movahedi A., Nemat-Gorgani M
Biochimica et Biophysica Acta, Vol.1804, Year. 2010, Page:714-722,

Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats

Authors: Najafian M, Ebrahim-Habibi A., Yaghmaei P, Parivar K, Larijani B
Acta Biochimica Polonica , Vol.57, Year. 2010, Page:553-560,

Amyloidogenic potential of alpha-chymotrypsin in different conformational states

Authors: . Rezaei-Ghaleh N., Zweckstetter M. ,Morshedi D., Ebrahim-Habibi A., Nemat-Gorgani M.
Biopolymers, Vol.91, Year. 2009, Page:28-36,

Thermal aggregation of a model allosteric protein in different conformational states.

Authors: Sabbaghian M.,Ebrahim-Habibi A., Nemat-Gorgani M
International Journal of Biological Macromolecules, Vol.44, Year. 2009, Page:156-162,

Mutation screening of VHL gene in a family with malignant bilateral pheochromocytoma: from isolated familial pheochromocytoma to von Hippel-Lindau disease

Authors: Hasani-Ranjbar S, Amoli MM, Ebrahim-Habibi A,Haghpanah V, Hejazi M, Soltani A, Larijani B
Familial Cancer, Vol.8, Year. 2009, Page:465-471.,

Thermal aggregation of α-chymotrypsin: Role of hydrophobic and electrostatic interactions

Authors: Rezaei-Ghaleh N., Ramshini H., Ebrahim-Habibi A.,Moosavi-Movahedi AA. , Nemat-Gorgani M.
Biophysical Chemistry, Vol.132, Year. 2008, Page:23-32,

Thermally induced changes in the structure and activity of yeast hexokinase B

Authors: Ramshini H., Rezaei-Ghaleh N., Ebrahim-Habibi A., Saboury AA, Nemat-Gorgani M.
Biophysical Chemistry, Vol.137, Year. 2008, Page:88-94.,

-Role of electrostatic interactions in 2,2,2-trifluoroethanol-induced structural changes and aggregation of α-chymotrypsin

Authors: Rezaei-Ghaleh N., Ebrahim-Habibi A., Moosavi-Movahedi AA.,Nemat-Gorgani M
Archives of Biochemistry and Biophysics, Vol.457, Year. 2007, Page:160-169,

Effect of polyamines on the structure, thermal stability and 2,2,2-trifluoroethanol-induced aggregation of α-chymotrypsin

Authors: Rezaei-Ghaleh N., Ebrahim-Habibi A.,Moosavi-Movahedi AA., Nemat-Gorgani M.
International Journal of Biological Macromolecules, Vol.41, Year. 2007, Page:597-604,

Inhibition of amyloid fibrillation of lysozyme by indole derivatives : possible mechanism of action.

Authors: Morshedi D.,Rezaei-Ghaleh N., Ebrahim-Habibi A., Ahmadian S., Nemat-Gorgani M.
FEBS Journal , Vol.274, Year. 2007, Page:6415–6425,

Thermostabilization of Bacillus amyloliquefaciens alpha-amylase by chemical crosslinking

Authors: Ebrahim-Habibi A. ,Khajeh K., Naderi-Manesh H., Ranjbar B., Nemat-Gorgani M
Journal of Biotechnology, Vol.123, Year. 2006, Page:434-442,

-Chemical modification of lysine residues in Bacillus licheniformis alpha-amylase: conversion of an endo- to an exo-type enzyme.

Authors: Ebrahim-Habibi A., Khajeh K., Nemat-Gorgani M.
Journal of Biochemistry and Molecular Biology, Vol.37, Year. 2004, Page:642-647,

Interaction of an intermediate structure of Bacillus subtilis alpha-amylase with alkyl-substituted sepharose 4B: a model of membrane translocation

Authors: Karbalaei-Heidari HR., Ebrahim Habibi A., Khajeh K.,Ranjbar B., Nemat-Gorgani M.
Applied Biochemistry and Biotechnology, Vol.117, Year. 2004, Page:123-32,

Chemical modification of bacterial alpha-amylases: changes in tertiary structures and the effect of additional calcium

Authors: Khajeh K., Ranjbar B., Naderi-Manesh H., Ebrahim Habibi A., Nemat-Gorgani M
Biochimica et Biophysica Acta, Vol.1548, No.2, Year. 2001, Page:229-37,

Abstracts and Presentations



(Pondering over multiple facets of protein aggregation (from models to diseases

The 3rd Conference on Protein and Peptide Sciences
Location: Shiraz,
Date: 2018-Type : Oral Presentation & Abstract, Lecturer,

Looking at the aggregation process of proteins at different levels:use of in silico, in vitro and in vivo models

(Protein Folding and Stability (3rd IASBS Symposium in Biological Sciences
Location: Zanjan,
Date: 2017-Type : Oral Presentation & Abstract, Lecturer,

Homology modelling of human Maltase enzyme and in silico characterization of its active site

Archives of Iranian Medicine
Date: October 2007-Type : Abstract, No: p420 (S141), Suppl: 1, Volume: 10, Issue: 4, others,

An in silico study on the inhibitor selectivity of Cathepsin G

Date: October 2007-Type : Abstract, Journal: Archives of Iranian Medicine, No: p428 (S143-144), Suppl: 1, Volume: 10, Issue: 4, others,

Thermal aggregation of Bacillus amyloliquefaciens alpha-amylase: effect of amino acids

Date: 2008-Type : Abstract, Journal: FEBS Journal, No: 189, Suppl: 1, Volume: 275, others,

Inhibitors of insulin amyloid formation: an in silico study

Date: 2008-Type : Abstract, Journal: FEBS Journal, No: 165, Suppl: 1, Volume: 275, others,

Flavonoids as potential antihyperglycemics: an in silico study of their alpha-amylase inhibitory mode.

Date: 2008-Type : Abstract, Journal: Drugs of the Future, No: 306-307, Suppl: A, Volume: 33, others,

Molecular modelling studies on alpha-glucosidase interaction with inhibitors

Proceedings of the 2nd Iranian Conference on Bioinformatics
Date: 2008-Type : Abstract, Volume: 8, Issue: 9, others,

Curcumin inhibits mammalian alpha-amylase

Date: 2009-Type : Abstract, Journal: Proccedings of VIII European Symposium of The Protein Society , others,

-Design of new alpha-glucosidase inhibitors based on molecular modeling studies

Date: 2009-Type : Abstract, Journal: Journal of the Iranian Chemical Society, No: 90, Suppl: 1, Volume: 6, Issue: O-10, others,

Molecular modeling studies on cholesterol esterase inhibitors: proposition of new ligands , and insight into possible additional

Date: 2010-Type : Abstract, Journal: 3rd Iranian Conference on Bioinformatics, Volume: 5-6, others,

Proposal Of Novel Nad+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Inhibitors Based On A Molecular Modeling Study.

Date: 2010-Type : Abstract, Journal: Drugs of the Future, Suppl: Suppl.A, Volume: 35, others,

Molecular Modeling Study on Palmitate Binding Site in Echovirus Coat Protein: Proposing an Antiviral Target

Larijani B.Proceedings of the 6th International Symposium on Health Informatics and Bioinformatics,(
Location: Izmir, Turkey,
Date: 2011-Type : Abstract, others,

Journal of Diabetes and Metabolic Disorders

2012- Editor,

Section Editor (Interdisciplinary Medicine)


Iran Society of Biophysical Chemistry

Activity Type:عضو هیئت مدیره

Iran Bioinformatics Society

Activity Type:Member

Iran Endocrine Society

Activity Type:سایر
1. Protein Structure, Protein Aggregation, Molecular Modeling, Enzymology